In this study are present challenges of the United States relating weapons policing, weapons manufacturing and distribution, proliferation and use of firearms presented. Such challenges are among others the examination of the second change of the Constitution of the United States in the question of law interpretation of individual weapons regulation, the balance of state and union power regarding possession of firearms, historical coherences and evaluation of the present situation, and further the presentation of lobbying activities of weapons industry. In this research is intended to highlight a socially, economically and politically determining circle of phenomena in the aspect of factual data. In certain periods of the presidential election of 2016 and after the election both in press and in politics (and in a certain sense also in the scientific works of this professional field) became conspicuous the topic of role assumption and interference of firearm producers and firearm distributors. Identification and clearing of the problem need analyses of the second change o the Constitution of the United States, which can help to clarify certain problems of the weapons regulation in the United States, and motivations of weapons manufacturing groups in their lobbying activities.